4910-Chalasani, Naga

Naga P. Chalasani, MD

David W. Crabb Professor of Gastroenterology and Hepatology

Professor of Medicine

Adjunct Professor of Anatomy, Cell Biology & Physiology

Address
702 Rotary Circle, Suite 225

Indianapolis, IN 46202
PubMed:

Bio

Dr. Chalasani completed medical school in India before he moved to the U.S. to pursue Internal Medicine residency at Emory University in Atlanta, followed by a fellowship in Gastroenterology and Hepatology at the same institution. He joined IU in 1997 as an Assistant Professor in the Division of Gastroenterology and Hepatology. Dr. Chalasani is currently David W. Crabb Professor of Gastroenterology and Hepatology and Adjunct Professor of Anatomy, Cell Biology & Physiology and as Director of Terance Kahn Liver Research Program at Indiana University School of Medicine. He previously served as the GI Division Chief (2007-2020), Associate Dean for Clinical Research (2017-2020) interim Chair of the Department of Medicine (2020-2021) and Vice President for Academic Affairs at Indiana University Health (2022-2024). He is a highly regarded clinician and ranked as Top Doctor continuously for over 15 years. He has been continuously funded by the National Institutes of Health (NIH) since 1999 and is currently the PI on several U01 and R01 awards from the NIH. Dr. Chalasani is considered an authority in the fields of Non-Alcoholic Fatty Liver Disease (NAFLD) and Drug Induced Liver Injury (DILI), two highly significant public health problems. He is one of the most published and most cited investigators at Indiana University, with Google Scholar H-Index 120 and 75,000 citations (as of Feb 2025). He is an elected member of the American Society of Clinical Investigation (ASCI), the American Association of Physicians (AAP) and the National Academy of Medical Sciences – India (2024). He has mentored over 75 undergraduate and graduate students, medical students, sub-specialty trainees, and junior faculty. Twenty of his mentees are recipients of federal funding (K award, U01, R21, R01, DOD, and VA Merit Review). To honor his contributions and mentorship, Naga P Chalasani Endowed Professor in Gastroenterology and Hepatology has been established at Indiana University School of Medicine in October 2022.

Key Publications

  1. Vilar-Gomez E, Vuppalanchi R, Gawrieh S, Pike F, Samala N, Chalasani N. Significant Dose-Response Association of Physical Activity and Diet Quality With Mortality in Adults With Suspected NAFLD in a Population Study. Am J Gastroenterol. 2023 Sep 1;118(9):1576-1591. doi: 10.14309/ajg.0000000000002222. Epub 2023 Feb 16. PMID: 36799895.
  2. Powell NR, Liang T, Ipe J, Cao S, Skaar TC, Desta Z, Qian HR, Ebert PJ, Chen Y, Thomas MK, Chalasani N. Clinically important alterations in pharmacogene expression in histologically severe nonalcoholic fatty liver disease. Nat Commun. 2023 Mar 17;14(1):1474. doi: 10.1038/s41467-023-37209-1. PMID: 36927865; PMCID: PMC10020163.
  3. Nicoletti P, Dellinger A, Li YJ, Barnhart H, Phillips E, Chalasani N; Drug Induced Liver Injury Network (DILIN) investigators. HLA-B*53:01 Is a Significant Risk Factor of Liver Injury due to Phenytoin and Other Antiepileptic Drugs in African Americans. Am J Gastroenterol. 2024 Jan 1;119(1):200-202. doi: 10.14309/ajg.0000000000002454. Epub 2023 Aug 8. PMID: 37552102; PMCID: PMC10841235.
  4. Jarasvaraparn C, Vilar-Gomez E, Yates KP, Wilson LA, Neuschwander-Tetri B, Loomba R, Cummings O, Vos M, Xanthakos S, Schwimmer J, Molleston JP, Sanyal A, Tonascia J, Chalasani N. Age, BMI, and Type 2 Diabetes Modify the Relationship Between PNPLA3 and Advanced Fibrosis in Children and Adults With NAFLD. Clin Gastroenterol Hepatol. 2024 May;22(5):1024-1036.e2. doi: 10.1016/j.cgh.2023.12.009. Epub 2023 Dec 23. PMID: 38145725; PMCID: PMC11045318.
  5. Gawrieh S, Dasarathy S, Tu W, Kamath PS, Chalasani NP, McClain CJ, Bataller R, Szabo G, Tang Q, Radaeva S, Barton B, Nagy LE, Shah VH, Sanyal AJ, Mitchell MC; AlcHepNet Investigators. Randomized trial of anakinra plus zinc vs. prednisone for severe alcohol-associated hepatitis. J Hepatol. 2024 May;80(5):684-693. doi: 10.1016/j.jhep.2024.01.031. Epub 2024 Feb 10. PMID: 38342441; PMCID: PMC11214682.
  6. Samala N, Xin Y, Wilson LA, Yates K, Loomba R, Hoofnagle JH, Chalasani N; NASH Clinical Research Network. Non-Hispanic Black Persons With Nonalcoholic Fatty Liver Disease Have Lower Rates of Advanced Fibrosis, Cirrhosis, and Liver-Related Events Even After Controlling for Clinical Risk Factors and PNPLA3 Genotype. Am J Gastroenterol. 2024 Sep 1;119(9):1857-1865. doi: 10.14309/ajg.0000000000002756. Epub 2024 May 14. PMID: 38483303; PMCID: PMC11399313.
  7. Chalasani N, Vilar-Gomez E, Loomba R, Yates KP, Diehl AM, Neuschwander-Tetri BA, Dasarathy S, Kowdley KV, Terrault N, Wilson LA, Tonascia J, Sanyal AJ. PNPLA3 rs738409, age, diabetes, sex, and advanced fibrosis jointly contribute to the risk of major adverse liver outcomes in metabolic dysfunction-associated steatotic liver disease. Hepatology. 2024 Nov 1;80(5):1212-1226. doi: 10.1097/HEP.0000000000000896. Epub 2024 Apr 23. PMID: 38652636; PMCID: PMC11798878.
  8. Gawrieh S, Vilar-Gomez E, Wilson LA, Pike F, Kleiner DE, Neuschwander-Tetri BA, Diehl AM, Dasarathy S, Kowdley KV, Hameed B, Tonascia J, Loomba R, Sanyal AJ, Chalasani N; NASH Clinical Research Network. Increases and decreases in liver stiffness measurement are independently associated with the risk of liver-related events in NAFLD. J Hepatol. 2024 Oct;81(4):600-608. doi: 10.1016/j.jhep.2024.05.008. Epub 2024 May 16. PMID: 38762169; PMCID: PMC11410523.
  9. Alkhouri N, McCarthy D, Bayne AV, Blonquist T, Yurko-Mauro K, Vuppalanchi R, Lawitz E, Chalasani N. The effect of vitamin E and docosahexaenoic acid ethyl ester on Metabolic Dysfunction-Associated steatotic Liver Disease (MASLD)-A randomised, double-blind, placebo-controlled, parallel-group clinical trial (PUVENAFLD). Aliment Pharmacol Ther. 2024 Sep;60(5):552-562. doi: 10.1111/apt.18149. Epub 2024 Jul 12. PMID: 39001559.

Looking for patient care?

To schedule an appointment with a faculty member physician of IU School of Medicine, contact Indiana University Health at 888-484-3258 or use the physician finder by clicking the button below.