
Naga P. Chalasani, MD
David W. Crabb Professor of Gastroenterology and Hepatology
Professor of Medicine
Adjunct Professor of Anatomy, Cell Biology & Physiology
Bio
Dr. Chalasani completed medical school in India before he moved to the U.S. to pursue Internal Medicine residency at Emory University in Atlanta, followed by a fellowship in Gastroenterology and Hepatology at the same institution. He joined IU in 1997 as an Assistant Professor in the Division of Gastroenterology and Hepatology. Dr. Chalasani is currently David W. Crabb Professor of Gastroenterology and Hepatology and Adjunct Professor of Anatomy, Cell Biology & Physiology and as Director of Terance Kahn Liver Research Program at Indiana University School of Medicine. He previously served as the GI Division Chief (2007-2020), Associate Dean for Clinical Research (2017-2020) interim Chair of the Department of Medicine (2020-2021) and Vice President for Academic Affairs at Indiana University Health (2022-2024). He is a highly regarded clinician and ranked as Top Doctor continuously for over 15 years. He has been continuously funded by the National Institutes of Health (NIH) since 1999 and is currently the PI on several U01 and R01 awards from the NIH. Dr. Chalasani is considered an authority in the fields of Non-Alcoholic Fatty Liver Disease (NAFLD) and Drug Induced Liver Injury (DILI), two highly significant public health problems. He is one of the most published and most cited investigators at Indiana University, with Google Scholar H-Index 120 and 75,000 citations (as of Feb 2025). He is an elected member of the American Society of Clinical Investigation (ASCI), the American Association of Physicians (AAP) and the National Academy of Medical Sciences – India (2024). He has mentored over 75 undergraduate and graduate students, medical students, sub-specialty trainees, and junior faculty. Twenty of his mentees are recipients of federal funding (K award, U01, R21, R01, DOD, and VA Merit Review). To honor his contributions and mentorship, Naga P Chalasani Endowed Professor in Gastroenterology and Hepatology has been established at Indiana University School of Medicine in October 2022.
Key Publications
- Vilar-Gomez E, Vuppalanchi R, Gawrieh S, Pike F, Samala N, Chalasani N. Significant Dose-Response Association of Physical Activity and Diet Quality With Mortality in Adults With Suspected NAFLD in a Population Study. Am J Gastroenterol. 2023 Sep 1;118(9):1576-1591. doi: 10.14309/ajg.0000000000002222. Epub 2023 Feb 16. PMID: 36799895.
- Powell NR, Liang T, Ipe J, Cao S, Skaar TC, Desta Z, Qian HR, Ebert PJ, Chen Y, Thomas MK, Chalasani N. Clinically important alterations in pharmacogene expression in histologically severe nonalcoholic fatty liver disease. Nat Commun. 2023 Mar 17;14(1):1474. doi: 10.1038/s41467-023-37209-1. PMID: 36927865; PMCID: PMC10020163.
- Nicoletti P, Dellinger A, Li YJ, Barnhart H, Phillips E, Chalasani N; Drug Induced Liver Injury Network (DILIN) investigators. HLA-B*53:01 Is a Significant Risk Factor of Liver Injury due to Phenytoin and Other Antiepileptic Drugs in African Americans. Am J Gastroenterol. 2024 Jan 1;119(1):200-202. doi: 10.14309/ajg.0000000000002454. Epub 2023 Aug 8. PMID: 37552102; PMCID: PMC10841235.
- Jarasvaraparn C, Vilar-Gomez E, Yates KP, Wilson LA, Neuschwander-Tetri B, Loomba R, Cummings O, Vos M, Xanthakos S, Schwimmer J, Molleston JP, Sanyal A, Tonascia J, Chalasani N. Age, BMI, and Type 2 Diabetes Modify the Relationship Between PNPLA3 and Advanced Fibrosis in Children and Adults With NAFLD. Clin Gastroenterol Hepatol. 2024 May;22(5):1024-1036.e2. doi: 10.1016/j.cgh.2023.12.009. Epub 2023 Dec 23. PMID: 38145725; PMCID: PMC11045318.
- Gawrieh S, Dasarathy S, Tu W, Kamath PS, Chalasani NP, McClain CJ, Bataller R, Szabo G, Tang Q, Radaeva S, Barton B, Nagy LE, Shah VH, Sanyal AJ, Mitchell MC; AlcHepNet Investigators. Randomized trial of anakinra plus zinc vs. prednisone for severe alcohol-associated hepatitis. J Hepatol. 2024 May;80(5):684-693. doi: 10.1016/j.jhep.2024.01.031. Epub 2024 Feb 10. PMID: 38342441; PMCID: PMC11214682.
- Samala N, Xin Y, Wilson LA, Yates K, Loomba R, Hoofnagle JH, Chalasani N; NASH Clinical Research Network. Non-Hispanic Black Persons With Nonalcoholic Fatty Liver Disease Have Lower Rates of Advanced Fibrosis, Cirrhosis, and Liver-Related Events Even After Controlling for Clinical Risk Factors and PNPLA3 Genotype. Am J Gastroenterol. 2024 Sep 1;119(9):1857-1865. doi: 10.14309/ajg.0000000000002756. Epub 2024 May 14. PMID: 38483303; PMCID: PMC11399313.
- Chalasani N, Vilar-Gomez E, Loomba R, Yates KP, Diehl AM, Neuschwander-Tetri BA, Dasarathy S, Kowdley KV, Terrault N, Wilson LA, Tonascia J, Sanyal AJ. PNPLA3 rs738409, age, diabetes, sex, and advanced fibrosis jointly contribute to the risk of major adverse liver outcomes in metabolic dysfunction-associated steatotic liver disease. Hepatology. 2024 Nov 1;80(5):1212-1226. doi: 10.1097/HEP.0000000000000896. Epub 2024 Apr 23. PMID: 38652636; PMCID: PMC11798878.
- Gawrieh S, Vilar-Gomez E, Wilson LA, Pike F, Kleiner DE, Neuschwander-Tetri BA, Diehl AM, Dasarathy S, Kowdley KV, Hameed B, Tonascia J, Loomba R, Sanyal AJ, Chalasani N; NASH Clinical Research Network. Increases and decreases in liver stiffness measurement are independently associated with the risk of liver-related events in NAFLD. J Hepatol. 2024 Oct;81(4):600-608. doi: 10.1016/j.jhep.2024.05.008. Epub 2024 May 16. PMID: 38762169; PMCID: PMC11410523.
- Alkhouri N, McCarthy D, Bayne AV, Blonquist T, Yurko-Mauro K, Vuppalanchi R, Lawitz E, Chalasani N. The effect of vitamin E and docosahexaenoic acid ethyl ester on Metabolic Dysfunction-Associated steatotic Liver Disease (MASLD)-A randomised, double-blind, placebo-controlled, parallel-group clinical trial (PUVENAFLD). Aliment Pharmacol Ther. 2024 Sep;60(5):552-562. doi: 10.1111/apt.18149. Epub 2024 Jul 12. PMID: 39001559.
Year | Degree | Institution |
---|---|---|
1997 | Fellowship | Emory University School of Medicine |
1994 | Residency | Emory University School of Medicine |
1988 | MD | Kakatiya Medical College |
Non-Alcoholic Fatty Liver Disease (NAFLD), Drug Hepatotoxicity, Drug Metabolism
Nephew LD; Wang Y; Mohamed K; Nichols D; Rawl SM; Orman E; Desai AP; Patidar KR; Ghabril M; Chalasani N; Kasting ML; Journal of viral hepatitis 2022 Mar 7
Guardiola J; Lammert C; Teal E; Chalasani N; Journal of hepatology 2022 Mar 5
Vilar-Gomez E; Pirola CJ; Sookoian S; Wilson LA; Liang T; Chalasani N; Hepatology (Baltimore, Md.) 2022 Mar 29
Lammert C; Toal E; Mathur K; Khungar V; House M; Roberts LR; Reddy KR; Chalasani N; The American journal of gastroenterology 2022 Mar 23
Brandman D; Boyle M; McPherson S; Van Natta ML; Sanyal AJ; Kowdley K; Neuschwander-Tetri B; Chalasani N; Abdelmalek MF; Terrault NA; McCullough A; Bettencourt R; Caussy C; Kleiner DE; Behling C; Tonascia J; Anstee QM; Loomba R; Members of the Nonalcoholic Steatohepatitis Clinical Research Network.; Alimentary pharmacology & therapeutics 2022 Mar 17
Whitfield JB; Schwantes-An TH; Darlay R; Aithal GP; Atkinson SR; Bataller R; Botwin G; Chalasani NP; Cordell HJ; Daly AK; Day CP; Eyer F; Foroud T; Gleeson D; Goldman D; Haber PS; Jacquet JM; Liang T; Liangpunsakul S; Masson S; Mathurin P; Moirand R; McQuillin A; Moreno C; Morgan MY; Mueller S; Müllhaupt B; Nagy LE; Nahon P; Nalpas B; Naveau S; Perney P; Pirmohamed M; Seitz HK; Soyka M; Stickel F; Thompson A; Thursz MR; Trépo E; Morgan TR; Seth D; GenomALC Consortium.; Journal of hepatology 2022 Mar 11
Soma D; Park Y; Mihaylov P; Ekser B; Ghabril M; Lacerda M; Chalasani N; Mangus RS; Kubal CA; Transplantation direct 2022 Jan 5
Muthiah MD; Smirnova E; Puri P; Chalasani N; Shah VH; Kiani C; Taylor S; Mirshahi F; Sanyal AJ; Hepatology communications 2022 Jan 4
Devarbhavi H; Ghabril M; Barnhart H; Patil M; Raj S; Gu J; Chalasani N; Bonkovsky HL; Liver international : official journal of the International Association for the Study of the Liver 2022 Feb 7
Patidar KR; Naved MA; Grama A; Adibuzzaman M; Ali AA; Slaven JE; Desai AP; Ghabril MS; Nephew L; Chalasani N; Orman ES; Journal of hepatology 2022 Feb 22
Orman ES; Yousef A; Xu C; Shamseddeen H; Johnson AW; Nephew L; Ghabril M; Desai AP; Patidar KR; Chalasani N; Journal of pain and symptom management 2022 Feb 21
Huang R; Rao H; Lv F; Nan Y; Ren W; Huang Y; Li J; Tang H; Huang Y; Chalasani N; Wei L; Therapeutic innovation & regulatory science 2022 Feb 16
Mohamed KA; Ghabril M; Desai A; Orman E; Patidar KR; Holden J; Rawl S; Chalasani N; Kubal CS; Nephew L; Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2022 Apr 7
Woreta TA; Van Natta ML; Lazo M; Krishnan A; Neuschwander-Tetri BA; Loomba R; Mae Diehl A; Abdelmalek MF; Chalasani N; Gawrieh S; Dasarathy S; Vuppalanchi R; Siddiqui MS; Kowdley KV; McCullough A; Terrault NA; Behling C; Kleiner DE; Fishbein M; Hertel P; Wilson LA; Mitchell EP; Miriel LA; Clark JM; Tonascia J; Sanyal AJ; NASH Clinical Research Network.; PloS one 2022 Apr 15
Vilar-Gomez E; Vuppalanchi R; Mladenovic A; Samala N; Gawrieh S; Newsome PN; Chalasani N; Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2021 Dec 25
Chalasani NP; Crabb DW; Rex DK; Gastroenterology 2017 Sep 5
Wattacheril J; Lavine JE; Chalasani NP; Guo X; Kwon S; Schwimmer J; Molleston JP; Loomba R; Brunt EM; Chen YI; Goodarzi MO; Taylor KD; Yates KP; Tonascia J; Rotter JI; The Journal of pediatrics 2017 Sep 14
Puri P; Liangpunsakul S; Christensen JE; Shah VH; Kamath PS; Gores GJ; Walker S; Comerford M; Katz B; Borst A; Yu Q; Kumar DP; Mirshahi F; Radaeva S; Chalasani NP; Crabb DW; Sanyal AJ; TREAT Consortium.; Hepatology (Baltimore, Md.) 2017 Oct 30
Younossi ZM; Loomba R; Rinella ME; Bugianesi E; Marchesini G; Neuschwander-Tetri BA; Serfaty L; Negro F; Caldwell SH; Ratziu V; Corey KE; Friedman SL; Abdelmalek MF; Harrison SA; Sanyal AJ; Lavine JE; Mathurin P; Charlton MR; Chalasani NP; Anstee QM; Kowdley KV; George J; Goodman ZD; Lindor K; Hepatology (Baltimore, Md.) 2017 Dec 9
Younossi ZM; Loomba R; Anstee QM; Rinella ME; Bugianesi E; Marchesini G; Neuschwander-Tetri BA; Serfaty L; Negro F; Caldwell SH; Ratziu V; Corey KE; Friedman SL; Abdelmalek MF; Harrison SA; Sanyal AJ; Lavine JE; Mathurin P; Charlton MR; Goodman ZD; Chalasani NP; Kowdley KV; George J; Lindor K; Hepatology (Baltimore, Md.) 2017 Dec 9
Beaudoin JJ; Long N; Liangpunsakul S; Puri P; Kamath PS; Shah V; Sanyal AJ; Crabb DW; Chalasani NP; Urban TJ; TREAT Consortium.; Scandinavian journal of gastroenterology 2017 Aug 4
Hayashi PH; Rockey DC; Fontana RJ; Tillmann HL; Kaplowitz N; Barnhart HX; Gu J; Chalasani NP; Reddy KR; Sherker AH; Hoofnagle JH; Drug-Induced Liver Injury Network (DILIN) Investigators.; Hepatology (Baltimore, Md.) 2017 Aug 26
Liang T; Chalasani NP; Williams KE; Sarasani V; Janga SC; Vuppalanchi R; Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2016 Oct 22
Vuppalanchi R; Chalasani N; Digestive diseases and sciences 2016 Mar 24
Ghabril M; Agarwal S; Lacerda M; Chalasani N; Kwo P; Tector AJ; Transplantation 2016 Jan
Bohm M; Vuppalanchi R; Chalasani N; Drug-Induced Liver Injury Network (DILIN); Hepatology (Baltimore, Md.) 2016 Feb 3
Wong VW; Chalasani N; Journal of hepatology 2016 Feb 26
Crabb DW; Bataller R; Chalasani NP; Kamath PS; Lucey M; Mathurin P; McClain C; McCullough A; Mitchell MC; Morgan TR; Nagy L; Radaeva S; Sanyal A; Shah V; Szabo G; NIAAA Alcoholic Hepatitis Consortia; Gastroenterology 2016 Feb 24
Carr RM; Dhir R; Mahadev K; Comerford M; Chalasani NP; Ahima RS; Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2016 Aug 25
Orman ES; Ghabril M; Chalasani N; Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2016 Apr 1
Saab S; Manne V; Nieto J; Schwimmer JB; Chalasani NP; Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2015 May 11
Eaton JE; Juran BD; Atkinson EJ; Schlicht EM; Xie X; de Andrade M; Lammert CS; Luketic VA; Odin JA; Koteish AA; Kowdley KV; Chopra KB; Hirschfield GM; Chalasani NP; Lazaridis KN; Alimentary pharmacology & therapeutics 2015 Mar 17
Navarro V; Chalasani NP; The American journal of gastroenterology 2015 Mar
Hayashi PH; Fontana RJ; Chalasani NP; Stolz AA; Talwalker JA; Navarro VJ; Lee WM; Davern TJ; Kleiner DE; Gu J; Hoofnagle JH; U.S. DILIN Investigators; Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2015 Feb 24
Asztalos BF; Horan MS; Horvath KV; McDermott AY; Chalasani NP; Schaefer EJ; PloS one 2014 Oct 9
Chalasani NP; Hayashi PH; Bonkovsky HL; Navarro VJ; Lee WM; Fontana RJ; Practice Parameters Committee of the American College of Gastroenterology; The American journal of gastroenterology 2014 Jun 17
Force J; Saxena R; Schneider BP; Storniolo AM; Sledge GW Jr; Chalasani N; Vuppalanchi R; Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2014 Apr 28
Yang CY; Ma X; Tsuneyama K; Huang S; Takahashi T; Chalasani NP; Bowlus CL; Yang GX; Leung PS; Ansari AA; Wu L; Coppel RL; Gershwin ME; Hepatology (Baltimore, Md.) 2014 Apr 1
Kleiner DE; Chalasani NP; Lee WM; Fontana RJ; Bonkovsky HL; Watkins PB; Hayashi PH; Davern TJ; Navarro V; Reddy R; Talwalkar JA; Stolz A; Gu J; Barnhart H; Hoofnagle JH; Drug-Induced Liver Injury Network (DILIN); Hepatology (Baltimore, Md.) 2013 Dec 18
Hayashi PH; Chalasani NP; CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2012 Aug 13
Chalasani NP; Sanyal AJ; Kowdley KV; Robuck PR; Hoofnagle J; Kleiner DE; Unalp A; Tonascia J; NASH CRN Research Group; Contemporary clinical trials 2008 Sep 10
Malireddy SR; Pinto AG; Chalasani NP; Gorski JC; Hall SD; Transplantation proceedings 2008 Jun
Alsatie M; Pandya P; Chalasani NP; Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2008 Feb
Fridell JA; Saxena R; Chalasani NP; Goggins WC; Powelson JA; Cummings OW; Transplantation 2007 Jan 15
Liangpunsakul S; Chalasani NP; Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2007 Aug
Alla V; Abraham J; Siddiqui J; Raina D; Wu GY; Chalasani NP; Bonkovsky HL; Journal of clinical gastroenterology 2006 Sep
Lim JR; Faught PR; Chalasani NP; Molleston JP; The Journal of pediatrics 2006 Jun
Deenadayalu VP; Orinion EJ; Chalasani NP; Yoo HY; Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2005 Mar
Chalasani NP; Valdecanas MA; Gopal AK; McGowan JE Jr; Jurado RL; Chest 1995 Oct
Acute and chronic liver disease, Fatty Liver, Non-Alcoholic Steatohepatitis (NASH), Drug Hepatotoxicity, Drug Metabolism
Desc: Member, AAP
Scope: National
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Desc: Member, ASCI
Scope: National
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Desc: Member, AOA
Scope: National
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